The NewT Study at Washington University

Funding: Hershey, PI;  (DK064832) 2016-2021
HRPO #201601135

Clinical Trials # (

The Hershey Lab and collaborators are studying how the brain is a target organ in diabetes. In particular, we are interested in how brain development and exposure to hyperglycemia and hypoglycemia interact to shape developmental trajectories of the brain and its functions. This work has led to an understanding of the regional brain vulnerability in diabetes and has been funded for the past 10 years by the NIH (NIDDK). Collaborators on this work include: Neil White, M.D., Ana Maria Arbelaez, M.D., Kevin Black, M.D., and Josh Shimony, M.D.

The purpose of the NewT research study is to determine how symptoms at the time of Type 1 Diabetes Mellitus (T1DM) diagnosis, such as hyperglycemia and diabetic ketoacidosis (DKA) interact with age of onset to shape the development of the brain.

During both research visits (3 and 21 months post diagnosis) at WU and St. Louis Children’s Hospital, study participants will have a Mixed Meal Tolerance Test, complete a few thinking and memory tasks and undergo magnetic resonance imaging (MRI) of the brain. In addition, parents and participants are asked to fill out brief questionnaires. Data collected during each portion of the study visit are critical in helping us understand the neurological issues associated with Type 1 Diabetes and the brain.

Individuals diagnosed with T1DM in the past three months and their non-diabetic siblings between the ages of 4-16 years are needed for this research study. For more information or if you (your child/children) are interested in participating in the NewT Study please contact Samantha Ranck, MSW at (314) 362-6514 or You will be asked to complete a phone screen to determine your child’s eligibility.